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Volume 129, Issue 1

Mutations to Nitrofurantoin and Nitrofurazone Resistance in K12 Free

Abstract

The isolation and properties of nitrofurantoin- and nitrofurazone-resistant mutants have been compared. Nitrofurantoin-resistant mutants were easier to obtain and showed a higher resistance level. There was some cross-resistance at lower drug concentrations but not at higher levels. There was no difference in the UV resistance of most of the mutants obtained although a strain, AB2470, did yield nitrofurantoin-resistant mutants with increased UV resistance. This was however the only repair-defective strain which could be mutated to nitrofurantoin resistance. It is suggested that there is a mechanism for nitrofurantoin resistance in K12 which does not confer resistance to nitrofurazone and which may be associated with the repair of damaged DNA. This mechanism is in addition to that which also confers resistance to nitrofurazone.

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  • Published Online:
© Society for General Microbiology 1983
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1983-01-01
2024-04-27
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http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-129-1-99
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Mutations to Nitrofurantoin and Nitrofurazone Resistance in Escherichia coli K12
Microbiology 129, 99 (1983); https://doi.org/10.1099/00221287-129-1-99
/content/journal/micro/10.1099/00221287-129-1-99
/content/journal/micro/10.1099/00221287-129-1-99
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