1887

Abstract

This work describes isolation and characterization of mutants resistant to the lysine analogue -(2-aminoethyl)--cysteine (AEC). The mutation to AEC resistance was shown to affect the feedback regulation of aspartokinase; 70% of the mutants isolated had aspartokinase activity insensitive to concerted feedback inhibition by lysine plus threonine. Among these mutants, 70% (about 50% of the total AEC-resistant strains isolated) showed significant overproduction of -lactam antibiotics.

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/content/journal/micro/10.1099/00221287-129-7-2063
1983-07-01
2024-05-06
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