1887

Abstract

Mutants of blocked in cytodifferentiation regained their capacity to form differentiated mycelia and/or anthracycline pigments in the presence of butyrolactone-type autoregulatory effectors such as -2-(6′-methylheptanol-l′yl)-3-hydroxymethyl-4-butanolide. In the pertinent indicator strains, the effect has been correlated with the increase of lipid synthesis, with changes in the composition of lipid fraction and with the restoration of the production of neutral proteinases. The results suggest that autoregulatory butyrolactones from streptomycetes stimulate cytodifferentiation of their producers at an early stage of development.

Loading

Article metrics loading...

/content/journal/micro/10.1099/00221287-130-5-1237
1984-05-01
2024-04-30
Loading full text...

Full text loading...

/deliver/fulltext/micro/130/5/mic-130-5-1237.html?itemId=/content/journal/micro/10.1099/00221287-130-5-1237&mimeType=html&fmt=ahah

References

  1. Aharonowitz Y. 1980; Nitrogen-metabolite regulation of antibiotic biosynthesis. Annual Review of Microbiology 34:209–233
    [Google Scholar]
  2. Biro S., Vitalis S., Szabo G. 1980; A substance effecting differentiation in Streptomyces griseus.Purification and properties. European Journal of Biochemistry 103:359–363
    [Google Scholar]
  3. Bröker M., Pape H. 1981; NADP-glycohydrolase and macrotetrolide production in Streptomyces griseus. In Actinomycetes pp. 447–459 Edited by Schaal K. P., Pulverer G. Stuttgart: G. Fischer;
    [Google Scholar]
  4. Chater K. F., Merrick M. J. 1976; Approaches to the study of differentiation in Streptomyces coelicolor. In Genetics of Industrial Microorganisms pp. 583–589 Edited by MacDonald K. D. London: Academic Press;
    [Google Scholar]
  5. Eritt I., Gräfe U., Fleck W. F. 1982; A screening method for autoregulators of anthracycline-producing streptomycetes. Zeitschrift für allgemeine Mikrobiologie 22:91–95
    [Google Scholar]
  6. Eritt I., Elske G., Gräfe U., Fleck W. F. 1983; Influence of low molecular weight stimulators on differentiation of Streptomyces griseus. In Proceedings of the International Symposium on Genetics and Differentiation of Streptomycetes (held in Weimar, GDR, May 2-5, 1983) pp. 61 Jena, GDR: Central Institute of Microbiology;
    [Google Scholar]
  7. Eritt I., Reinhardt G., Gräfe U., Fleck W. F. 1984; Inducers of both cytodifferentiation and anthracycline biosynthesis of Streptomyces griseusand their occurrence in actinomycetes and other microorganisms. Zeitschrift für allgemeineMikrobiologie 24: (in the Press)
    [Google Scholar]
  8. Fleck W. F., Strauss D. 1975; Leukaemomycin, an antibiotic with antitumor activity. 1. Screening, fermentation and biological activity. Zeitschrift für allgemeine Mikrobiologie 15:495–503
    [Google Scholar]
  9. Ginther C. L. 1979; Sporulation and the production of serine proteinase and cephamycin C by Streptomyces lactamdurans. Antimicrobial Agents & Chemotherapy 15:522–526
    [Google Scholar]
  10. Gräfe U., Eritt I. 1983; On the biological inactivity of 4,5-dihydroxy-n-decanoic acid-4-lactones. Journal of Antibiotics 36:1592–1593
    [Google Scholar]
  11. Gräfe U., Eritt I., Fleck W. F. 1981; Evidence against a general role of NADP-glycohydrolase in cytodifferentiation of Streptomyces griseus. Journal of Antibiotics 34:1385–1387
    [Google Scholar]
  12. Gräfe U., Reinhardt G., Schade W., Krebs D., Eritt I., Fleck W. F., Heinrich E., Radics L. 1982a; Isolation and structure of novel autoregulators from Streptomyces griseus. Journal of Antibiotics 35:609–614
    [Google Scholar]
  13. Gräfe U., Schade W., Eritt I., Fleck W. F., Radics L. 1982b; A new inducer of anthracycline biosynthesis from Streptomyces viridochromogenes. Journal of Antibiotics 35:1722–1723
    [Google Scholar]
  14. Gräfe U., Reinhardt G., Krebs D., Roth M., Noack D. 1982c; Altered lipid composition in a non-differentiating derivative of Streptomyces hygroscopicus. Journal of General Microbiology 128:2693–2698
    [Google Scholar]
  15. Gräfe U., Reinhardt G., Eritt I., Schade W., Fleck W. F., Radics L. 1983a; Interspecific inducers of cytodifferentiation and anthracycline biosynthesis from Streptomyces bikiniensis and cyaneofuscatus. Biotechnology Letters 5:591–596
    [Google Scholar]
  16. Gräfe U., Reinhardt G., Eritt I., Fleck W. F., Steudel A. 1983b; Effect of the autoregulator from Streptomyces griseus on surface cultures of the blocked mutant JA 5142/86. Zeitschrift für allgemeine Mikrobiologie 23:559–565
    [Google Scholar]
  17. Hara O., Beppu T. 1982a; Mutants blocked in streptomycin production in Streptomyces griseus - the role of A-factor. Journal of Antibiotics 35:349–358
    [Google Scholar]
  18. Hara O., Beppu T. 1982b; Induction of streptomycin-inactivating enzyme by A-factor in Streptomyces griseus. Journal of Antibiotics 35:1208–1218
    [Google Scholar]
  19. Hopwood D. A. 1983; Actinomycete genetics and antibiotic production. In Biochemistry and Genetic Regulation of Commercially Important Antibiotics pp. 1–23 Edited by Vining L. C. Reading, Mass.: Addison-Wesley Publishing;
    [Google Scholar]
  20. Kalakoutski L. V., Agre N. S. 1976; Comparative aspects of development and differentiation in actinomycetes. Bacteriological Reviews 40:469–524
    [Google Scholar]
  21. Khokhlov A. S. 1982; Low molecular weight microbial bioregulators of secondary metabolism. In Overproduction of Microbial Products (FEMS Symposium no. 13) pp. 97–109 Edited by Krumphanzl V., Sikyta B., Vanek Z. London: Academic Press;
    [Google Scholar]
  22. Kleiner E. M., Onoprienko V. V., Pliner S. A., Soifer V. S., Khokhlov A. S. 1977; The synthesis of racemic A-factor, a bioregulator from Streptomyces griseus. Bioorganic Chemistry 3:424–426
    [Google Scholar]
  23. Murao S., Shimizu Y., Kameda M., Nishino T. 1982; Inhibition of sporulation of genus Bacillus by various microbial protease inhibitors. Agricultural and Biological Chemistry 46:3075–3077
    [Google Scholar]
  24. Pogell B. M. 1979; Regulation of aerial mycelium formation in streptomycetes. In Genetics of Industrial Microorganisms pp. 218–224 Edited by Sebek O. K., Laskin A. L. Madison, Wisconsin: American Society for Microbiology;
    [Google Scholar]
  25. Voronina O. I., Tovarova 1.1., Khokhlov A. S. 1978; Studies on the A-factor induced inhibition of glucose-6-phosphate dehydrogenase in Actinomyces streptomycini. Bioorganic Chemistry 4:1538–1546
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/micro/10.1099/00221287-130-5-1237
Loading
/content/journal/micro/10.1099/00221287-130-5-1237
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error