1887

Abstract

The aminoglycoside phosphotransferase (APH)(3′)(5″)-III has been characterized from BM4200, which is resistant to high levels of aminoglycosides. The phosphotransferase was apparently chromosomally-encoded and was responsible for the high-level resistance. The enzyme was not notably pH-dependent, was heterogeneous after isoelectric focusing, with pI values of approximately 4·8 and 5·1, and had an apparent molecular weight of 32500 after SDS-PAGE.

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1984-07-01
2024-04-30
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