1887

Abstract

Three extracellular proteases produced by during growth in liquid medium were examined for their effects on human α-1-antitrypsin (α-1-AT). One of these proteases, tissue-destructive protease (TDP) destroyed completely the trypsin-inhibitory capacity of α-1-AT at protease: inhibitor molar ratios down to 0.002:1. After inactivation by TDP, the of α-1-AT was reduced by 5000 in SDS-PAGE. This suggested that inactivation entailed only limited cleavage.

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1988-02-01
2024-05-01
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