f The phenolic mycoside of Mycobacterium ulcerans: structure and taxonomic implications
- Authors: Mamadou Daffé, Anne Varnerot, Véronique Vincent Lévy-Frébault
- Microbiology, January 1992 138: 131-137, doi: 10.1099/00221287-138-1-131
- Subject: Pathogenicity And Molecular Microbiology
- Published Online:
Summary: Mycobacterium ulcerans and some pathogenic mycobacterial species elaborate wax A consisting of related longchain β-diol components (phthiocerol and related compounds) esterified by multimethyl-branched fatty acids. With the exception of M. ulcerans, wax A-containing mycobacteria also synthesize glycosylated phenol phthiocerol diester and related compounds: the so-called phenolic mycosides. In a deliberate effort to characterize this latter class of compounds in M. ulcerans, 20 strains were examined. Phenolic mycosides were found in two strains. Application of chemical analyses, including one- and two-dimensional NMR spectroscopy, allowed the structural elucidation of glycolipids identified as 3-O-methyl-α-l-rhamnosyl phenol phthiocerol diphthioceranate and related compounds which correspond to mycoside G, previously characterized in M. marinum by other investigators. As phenolic mycosides are highly species-specific molecules, this finding stresses the close phylogenetic link between M. marinum and M. ulcerans. Incidentally, a survey of the mycolate content of M. ulcerans showed that methoxymycolate could not be detected in three strains.
© Society for General Microbiology 1992 | Published by the Microbiology Society
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