1887

Abstract

Summary: Some capsulated group A and group C streptococci were found to produce both hyaluronic acid and hyaluronidase during active growth; thus confirming and extending the work of Pike (1948 ). In a group C strain, LM, the free hyaluronic acid in liquid culture represents an excess of synthesis over destruction, the balance being influenced by the aeration of the culture. Within the limits examined the degree of aeration did not, however, influence hyaluronidase or hyaluronic acid production by strains producing either the enzyme or its substrate exclusively. A non-capsulated, hyaluronidase producing mutant of strain LM was isolated but capsulated cells, free from this variant, also produced the enzyme. Evidence is presented that the spreading activity of strain LM preparations in rabbit dermis is due to hyaluronidase rather than to capsular material as suggested by Pradhan (1937).

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/content/journal/micro/10.1099/00221287-14-1-134
1956-02-01
2024-05-01
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References

  1. Crowley N. 1944; Hyaluronidase production by haemolytic streptococci of human origin. J. Path. Bact. 56:27
    [Google Scholar]
  2. Faber V., Rosendal K. 1954; Streptococcal hyaluronidase. II. Studies on the production of hyaluronic acid and hyaluronidase by representatives of aU types of hemolytic streptococci belonging to group A. Acta path, microbiol. scand. 35:159
    [Google Scholar]
  3. McClean D. 1941; The capsulation of streptococci and its relation to diffusion factor (hyaluronidase). J. Path. Bact. 53:13
    [Google Scholar]
  4. McClean D. 1943; Studies on diffusing factors. 2. Methods of assay of hyaluronidase and their correlation with skin diffusing activity. Biochem. J. 37:169
    [Google Scholar]
  5. MaClennan A.P. 1956; The isolation and characterization of a hyaluronidase produced by a capsulated strain of group C streptococcus. J. gen. Microbiol. 14:143
    [Google Scholar]
  6. Morison J.E. 1940; Capsulation of haemolytic streptococci in relation to colony formation. J. Path. Bact. 51:401
    [Google Scholar]
  7. Murray R.G.E., Pearce R.H. 1949; The detection and assay of hyaluronidase by means of mucoid streptococci. Canad. J. Res.E 27:254
    [Google Scholar]
  8. Pike R.M. 1946; A study of group A streptococci from healthy carriers with particular reference to mucoid polysaccharide production. J. infect. Dis. 79:148
    [Google Scholar]
  9. Pike R.M. 1948a; Streptococcal hyaluronic acid and hyaluronidase. I. Hyaluronidase activity of non-capsulated group A streptococci. J. infect. Dis. 83:1
    [Google Scholar]
  10. Pike R.M. 1948b; Streptococcal hyaluronic acid and hyaluronidase. II. Production and subsequent destruction of hyaluronic acid by certain strains of group A streptococci. J. infect. Dis 83:12
    [Google Scholar]
  11. Pradhan M.G. 1937; An investigation of the invasiveness of a strain of Streptococcus haemolyticus. Brit. J. exp. Path. 18:90
    [Google Scholar]
  12. Rogers H.J. 1954; The rate of formation of hyaluronidase, coagulase and total extracellular protein by strains of Staphylococcus aureus. J. gen. Microbiol. 10:209
    [Google Scholar]
  13. Russell B.E., Sherwood N.P. 1949; Studies on streptococci. II. The role of hyaluronidase in experimental streptococcal infection. J. infect. Dis. 84:81
    [Google Scholar]
  14. Sallmann B. 1951; The process of hyaluronidase formation by haemolytic streptococci. J. Bact. 62:741
    [Google Scholar]
  15. Seastone C.V. 1939; The virulence of group C hemolytic streptococci of animal origin. J. exp. Med. 70:361
    [Google Scholar]
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