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Volume 170, Issue 4

Resistance phenotype and virulence potential of strains isolated from different sources Open Access

Abstract

is a member of Enterobacterales, often considered an opportunistic pathogen. Recent reports have highlighted as an emerging pathogen harbouring virulence and resistance determinants.

Little information exists on virulence and resistance determinants in strains isolated from environmental, food, and clinical samples.

To determine the presence of resistance and virulence determinants and plasmid features in strains isolated from environmental, food, and clinical samples, as well as their phylogenetic relationship.

All strains tested showed resistance to β-lactams and quinolones but were sensitive to aminoglycosides and nitrofurans. However, even though fosfomycin resistance is considered a characteristic trait of , the resistance phenotype was only observed in 50 % of the strains; was the most prevalent BLEE gene (70 %), while the quinolone gene was observed in 60 % of the strains. Virulence genes were differentially observed in the strains, with adhesion-related genes being the most abundant, followed by toxin genes. Finally, all strains carried one to seven plasmid bands ranging from 7 to 125 kbps and harboured several plasmid addiction systems, such as ParDE, VagCD, and CcdAB in 80 % of the strains.

is an important emerging pathogen that may harbour resistance and virulence genes. Additionally, it has mobilizable genetic elements that may contribute to the dissemination of genetic determinants to other bacterial genera.

  • Received:
  • Accepted:
  • Published Online:
Keyword(s): emerging pathogen , L. adecarboxylata , plasmids , resistance and virulence
Funding
This study was supported by the:
  • Universidad de Sonora (Award USO413008356)
    • Principle Award Recipient: EdwinBarrios-Villa
© 2024 The Authors
  • This is an open-access article distributed under the terms of the Creative Commons Attribution License. This article was made open access via a Publish and Read agreement between the Microbiology Society and the corresponding author’s institution.
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2024-04-25
2024-05-04
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Resistance phenotype and virulence potential of Leclercia adecarboxylata strains isolated from different sources
Microbiology 170, 001457 (2024); https://doi.org/10.1099/mic.0.001457
/content/journal/micro/10.1099/mic.0.001457
/content/journal/micro/10.1099/mic.0.001457
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