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Volume 158, Issue 2

fruit extract modulates quorum sensing-controlled virulence factor production and biofilm formation in Free

Abstract

() is a south-east Asian tree more commonly known as ‘Jarul’. Research on health benefits suggests that the . plant contains phytomolecules that may have antioxidant, anti-diabetic and anti-obesity properties. However, antimicrobial activities have not been reported for this plant. The ability of fruit extract (LSFE) to antagonize cell-to-cell communication, expression of virulence genes and factors, and biofilm formation was evaluated in strain PAO1. Our results suggested that LSFE caused downregulation of quorum sensing (QS)-related genes ( and ) and their respective signalling molecules, -acylhomoserine lactones, without affecting the growth of PAO1. Significant inhibition of virulence factors: LasA protease, LasB elastase, and pyoverdin production, was also recorded. Application of LSFE to PAO1 biofilms increased bacterial susceptibility to tobramycin. These data suggest a possible role for quorum-quenching mechanisms unrelated to static or cidal effects, and also suggest that . could serve as a cost-effective source in the development of new QS-based antibacterial drugs.

  • Received:
  • Accepted:
  • Revised:
  • Published Online:
© 2012 SGM
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2012-02-01
2024-05-10
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Lagerstroemia speciosa fruit extract modulates quorum sensing-controlled virulence factor production and biofilm formation in Pseudomonas aeruginosa
Microbiology 158, 529 (2012); https://doi.org/10.1099/mic.0.052985-0
/content/journal/micro/10.1099/mic.0.052985-0
/content/journal/micro/10.1099/mic.0.052985-0
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